Welcome to the Chris Ford Lab

We are in the Pharmacology Department at the University of Colorado School of Medicine on the Anschutz Medical Campus.

Our lab examines how neuromodulators are encoded in the mesolimbic and nigrostriatal systems and how circuit dysfunctions in these areas contribute to neurological and psychiatric disorders. Dopamine, acetylcholine and serotonin play key roles in the basal ganglia and nucleus accumbens, controlling a variety of motivated behaviors including decision-making, action selection, motor skill learning, habit formation and reward processing. We use the combination of electrophysiology, 2-photon imaging, optogenetics, genetically encoded optical sensors, electrochemistry, in vivo fiber photometry and behavioral approaches to study how transmission mediated by these neuromodulators is encoded within mesolimbic and nigrostriatal circuits. By identifying the mechanisms regulating signaling we aim to identify the disruptions in these systems that underlie psychiatric disorders such as drug addiction and schizophrenia and neurological disorders such as Parkinson’s disease.